Examples of genes that can be targeted by nucleotide sequences selected by the methods of the present invention include, but are not limited to, microtubule-associated protein tau (encoded by the MAPT gene), brain acid soluble protein 1 (encoded by the BASP1 gene), or amyloid precursor protein (encoded by the APP gene).
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Conservation of proteins with PEST sequences among different species supports their functional signi***ance. Nucleotide sequences of any type can be ***yzed using the methods of the current invention. All of the sudden, her username appears on my current viewers list.
For example, natural variants of Tau protein can contain one or more amino acid substitutions selected from: RSH, RSL, D285N, V289A, K574T, L583V, G589V, N596K, N613H, P618L, P618S, G620V, S622N, K634M, S637F, V654M, E659V, K6861, G706R, R723W, or any combinations thereof.


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